As a child actress, Ferguson appeared on the television program Kids Incorporated for several years with Renee Sandstrom, who became a fellow member of Wild Orchid. Ferguson's well-scrubbed image on that show presents quite a contrast with the "hip-hop funk" image she has more recently begun to cultivate. Ferguson was the voice of Sally Brown in two Charlie Brown specials: It's Flashbeagle, Charlie Brown (1984), and Snoopy's Getting Married, Charlie Brown (1985). She also voiced Sally in the 1985 version of The Charlie Brown and Snoopy Show.

In July 2005, Ferguson had a guest role on the Rocket Power special, Reggie's Big Beach Break, on Nickelodeon; she voiced a fictitious pop music star named Shaffika. Ferguson returned to acting in 2006, appearing in a minor role in the film Poseidon. She later appeared in 2007's Grindhouse.